Muar or also known as Bandar Maharani is located about 175 km from the state capital of Johor, Johor Bahru. It has an area of 2346.12 km (square ) and population of 437 164 people (2007).

Sultanah Fatimah Specialist Hospital was established around 1900 in Jalan Petri, Muar and are also known as' Government Dispensary. The hospital has moved its location to Jalan Salleh 1918 when the Muar undergone the town planning. Since 1920's, the hospital which previously known as Muar Hospital has gone through rapid development.

The naming conversion and the declaration of the Hospital name to the Sultanah Fatimah Specialist Hospital was completed by His Highness the Sultanah Johor on October 13, 2003.
This hospital serves as the third ranked hospital in Johor after Sultanah Aminah Hospital and Sultan Ismail Hospital. It also serves as a reference hospital for the northern zone of Johor inclusive Batu Pahat, Tangkak and Segamat.

In addition Sultanah Fatimah Specialist Hospital also holds the role as 'Teaching Hospital'.
The Master Plan Developements begins since 1990 and we still waiting for ambulatory Care Centre Block that will equip the hospital with a variety of sophisticated medical equipment facilities to meet the specialized services provided.